Bupivacaine Liposomal Suspension for Injection

What is this medicine?

BUPIVACAINE LIPOSOMAL (bue PIV a kane LIP oh som al) is an anesthetic. It causes loss of feeling in the skin or other tissues. It is used to prevent and to treat pain from some procedures.

How should I use this medicine?

This medicine is for injection into the affected area. It is given by a health care professional in a hospital or clinic setting.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • seizures

  • signs and symptoms of a dangerous change in heartbeat or heart rhythm like chest pain; dizziness; fast, irregular heartbeat; palpitations; feeling faint or lightheaded; falls; breathing problems

  • signs and symptoms of methemoglobinemia such as pale, gray, or blue colored skin; headache; fast heartbeat; shortness of breath; feeling faint or lightheaded, falls; tiredness

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • anxious

  • back pain

  • changes in taste

  • changes in vision

  • constipation

  • dizziness

  • fever

  • nausea, vomiting

What may interact with this medicine?

This medicine may interact with the following medications:

  • acetaminophen

  • certain antibiotics like dapsone, nitrofurantoin, aminosalicylic acid, sulfonamides

  • certain medicines for seizures like phenobarbital, phenytoin, valproic acid

  • chloroquine

  • cyclophosphamide

  • flutamide

  • hydroxyurea

  • ifosfamide

  • metoclopramide

  • nitric oxide

  • nitroglycerin

  • nitroprusside

  • nitrous oxide

  • other local anesthetics like lidocaine, pramoxine, tetracaine

  • primaquine

  • quinine

  • rasburicase

  • sulfasalazine

What if I miss a dose?

This does not apply.

Where should I keep my medicine?

This drug is given in a hospital or clinic and will not be stored at home.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • G6PD deficiency

  • heart disease

  • kidney disease

  • liver disease

  • low blood pressure

  • lung or breathing disease, like asthma

  • an unusual or allergic reaction to bupivacaine, other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

What should I watch for while using this medicine?

Your condition will be monitored carefully while you are receiving this medicine.

Be careful to avoid injury while the area is numb, and you are not aware of pain.


NOTE:This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider. Copyright© 2021 Elsevier
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